Natural Organic Compounds That Affect to Microtubule Functions

Natural Compounds Modulating Mitochondrial Functions

Mitochondria are organelles responsible for several crucial cell functions, including respiration, oxidative phosphorylation, and regulation of apoptosis; they are also the main intracellular source of reactive oxygen species (ROS). In the last years, a particular interest has been devoted to studying the effects on mitochondria of natural compounds of vegetal origin, quercetin (Qu), resveratro...

Spotlight: Application of natural catalysts in the synthesis of organic compounds

Maryam Sadat Ghasemzadeh was born in Ghaen/ Southern Khorasan, Iran. She received her B.Sc. in Pure Chemistry from Imam Khomeini International University and M.Sc. in Organic Chemistry from Birjand University under the supervision of Professor Sara Sobhani. She is currently studying her Ph.D. in Ferdowsi University of Mashhad under the supervision of Professor Batool Akhlaghinia. Her current re...

Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function.

Three new genes affecting microtubule function in Saccharomyces cerevisiae were isolated by screening for mutants displaying supersensitivity to the antimicrotubule drug benomyl. Such mutants fall into six complementation groups: TUB1, TUB2 and TUB3, the three tubulin genes of yeast, and three new genes, which we have named CIN1, CIN2 and CIN4. Mutations in each of the CIN genes were also indep...

Anticancer Natural Compounds: Molecular Mechanisms and Functions. Part I

Anticancer Natural Compounds: Molecular Mechanisms and Functions 
Part II

In spite of enormous success achieved by the cancer biologists and clinical oncologists alike for the last decades, cancers still presents a great challenge for the researchers and suffering for the patients. While basic mechanisms underlying tumor initiation and progression are unraveling as we speak, as well as novel therapeutic strategies often appear in clinical practice the tumors defend t...